标题: A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance [打印本页] 作者: StephenW 时间: 2011-3-22 13:32 标题: A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance
J Infect Dis. 2011 Apr;203(7):943-947.
A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance
in Han Chinese.
An P, Winkler C, Guan L, O'Brien SJ, Zeng Z; the HBV Study Consortium.
Basic Research Laboratory.
Abstract
A recent genome-wide study showed that the single nucleotide polymorphisms
(SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV)
infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for
all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance,
chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T
was strongly associated with decreased risk of chronic HBV infection (odds
ratio, .62; P = .001), consistent with the previous report. We showed for the
first time to our knowledge that it is a predictor for HBV clearance (odds
ratio, 2.41; P < .001). However, rs3077 was not associated with the development
of cirrhosis or hepatocellular carcinoma.
PMID: 21402545 [PubMed - as supplied by publisher] 作者: StephenW 时间: 2011-3-22 13:33
.