liver411老师，本人小三阳15年了，DNA弱阳，差不多都是在500-5000之间徘徊，有时候又是阴性，肝功能一直都是正常的，十几年以来，最近刚做了fibroscan，结果是5.2kpa。但是我肝区不适已经6年了，而且经常觉得疲劳，肌肉关节酸痛。做了很多检查，都无法找出真正的原因。最近GP帮我做了个铁蛋白（ferritin）的检查，结果是355ug/l。正常值应该是（20=300）。我的肝功能的结果是： alt 20， ast 17，ggt 13， bilirubin 15， alp 59， albumin 48。我的医生排除是肝炎引起的ferritin升高，他现在怀疑有可能是基因方面的原因。而且说ferritin level 高会造成肝损害，最后硬化。他说如果确证是基因的原因，以后可能要长期放血。请问你， 我的ferritin高的原因是乙肝引起还是基因的因素更大？肝区不适跟ferritin有关系吗？还有355ug/l的水平需要放血吗？ 作者: keane 时间: 2011-2-24 09:47
Increased serum ferritin in chronic liver disease: a risk factor for primary hepatocellular carcinoma. (PMID:2538399)
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Hann HW,
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Kim CY,
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London WT,
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Blumberg BS
Fox Chase Cancer Center, Philadelphia, PA.
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International Journal of Cancer. Journal International du Cancer [1989, 43(3):376-9]
Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
DOI: 10.1002/ijc.2910430304
Abstract Highlight Terms Gene Ontology(2) Diseases(3) Genes/Proteins(1) Species(2)
Previous studies from this laboratory support the view that increased serum ferritin levels are associated with an increased risk of primary hepatocellular carcinoma (PHC). We have tested this hypothesis in a population of Korean patients with chronic liver disease followed for development of PHC. Serum ferritin levels were measured over time in 249 patients with liver diseases (mostly chronic) followed for 2 to 17 years in Seoul, Korea. Most of the patients were chronically infected with hepatitis B virus. During the first 8 months of follow-up, there were no cases of PHC and no deaths. During this same period, no patient had a serum ferritin level initially below 300 ng/ml and rising above 300 ng/ml, but some patients with ferritin levels above 300 ng/ml experienced decreases to below 300 ng/ml. Therefore, patients were grouped by ferritin level during the first 8 months of follow-up into 3 categories according to the above criteria. Multivariate analysis showed that consistently elevated ferritin levels (category 3) were significantly associated with the development of PHC. Men were more likely to have elevated ferritin levels than women and were at higher risk of developing PHC. Men who were chronically infected with HBV and had ferritin levels above 300 ng/ml had a 50% chance of developing PHC during the follow-up period, compared with a 20% risk of PHC for men with lower ferritin levels (categories 1 and 2). This elevated risk of PHC in men with elevated ferritin levels was confined to the first 3 years of follow-up. 作者: keane 时间: 2011-2-24 09:50
