标题: Viral factors and outcomes of chronic HBV infection. [打印本页] 作者: StephenW 时间: 2011-2-14 05:28 标题: Viral factors and outcomes of chronic HBV infection.
本帖最后由 风雨不动 于 2012-4-14 15:38 编辑
Am J Gastroenterol. 2011 Jan;106(1):93-5.
Viral factors and outcomes of chronic HBV infection.
Huang Y, Lok AS.
Comment on:
Am J Gastroenterol. 2011 Jan;106(1):81-92.
Abstract
Viral factors associated with outcome of chronic hepatitis B virus (HBV)
infection include hepatitis B e antigen status, HBV DNA, genotype, and HBV
variants. Mutations in the HBV core promoter region have been shown to be
independently associated with hepatocellular carcinoma (HCC). The most common
core promoter mutations involve a double substitution A1762T and G1764A (TA).
Besides TA mutations, several other core promoter changes have been reported to
be associated with the development of cirrhosis and HCC. Future studies should
determine if detection of these changes can predict the outcome of patients with
chronic HBV infection.
PMID: 21212756 [PubMed - indexed for MEDLINE]
上午胃肠病学。 2011年一月，106（1）:93- 5。