| In a univariate analysis, both the chronic hepatitis B and previous exposure groups were more likely to develop HCC compared with the negative cohort (2.2%, 0.8%, and 0.2%, respectively). |
| The previous exposure cohort was older, on average, than the other 2 groups. |
| The chronic hepatitis B and previous exposure groups were also more likely to have the following characteristics, compared with the negative group: |
| | Asian: 6.4%, 2.4%, and 0.9%, respectively; | | Male: 66.8%, 61.1%, and 49.5%, respectively; | | HIV positive: 14.6%, 9.3%, and 1.6%, respectively. |
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| In a multivariate analysis taking into account factors including sex, age, race/ethnicity, HIV status, and diabetes, previous HBV exposure and chronic hepatitis B were both strong and significant predictors of HCC: |
| | Previous exposure vs negative: odds ratio (OR) 3.06; | | Chronic hepatitis B vs previous exposure: OR 3.09; | | Chronic hepatitis B vs negative: OR 3.084. |
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| [size=-1]Race/ethnicity was not a significant predictive factor in any of these analyses. |